High Pollen May Trigger Mysterious Flares of Chronic Bladder Pain in Some People

Those people of us with hay fever are painfully familiar with the annoyance induced by days of significant pollen – the incessant leaking of eye and nose mucus, itchy ears, eyes and throat, bursting matches of sneezes, and at times head aches and bronchial asthma. Now, a new review implies that in persons with a serious pelvic ailment, higher pollen could also be triggering bouts of pelvic discomfort.


Much more than 10 million people in the US reside with the mysterious established of situations known as urologic chronic pelvic pain syndrome (UCPPS) – a cluster of issues that incorporate bladder pain syndrome and interstitial cystitis in women of all ages, long-term pelvic pain syndrome, and long-term prostatitis in males. They can cause debilitating symptoms like an urgent and recurrent have to have to urinate, agony inside of the pelvic location, and painful intercourse. 

Researchers have known as UCPPS “one particular of the most frustrating urologic circumstances to realize and deal with” due to the fact its causes are even now unfamiliar as are its triggers of irritating signs or symptoms. A prognosis of interstitial cystitis in gals, for instance, can involve bladder inflammation where all other doable acknowledged leads to have been ruled out. 

Almost everything from germs to psychological triggers have been examined devoid of a lot clarification.

Having said that, circumstance stories have proposed asthma and allergy drugs can decrease UCPPS indications and patients have described flare-ups coinciding with other allergy symptoms. So Washington University epidemiologist Siobhan Sutcliffe and colleagues decided to get a closer glimpse at UCPPS’s connection with a very well-known allergen.

The workforce compared 290 patient’s flare-ups with pollen degrees and found that even though everyday improvements in pollen counts did not appear to be related, when pollen costs exceeded a “medium” threshold signs flared up by 22 percent 1 or two times afterwards.


“Our analyze gives evidence to advise amplified pollen counts may well trigger symptom flares in men and women living with UCPPS,” said Sutcliffe.

The properly-identified course of action of mast cell activation in allergies that releases the histamines they have is suspected to lead to some of these UCPPS situations. Animal experiments have shown extended higher levels of histamine in the bladder can make the bladder’s nerves hypersensitive. And histamines in urine surface to continue to be elevated for for a longer period than in our blood as our bodies use this exit pathway to take away them.

The new exploration adds to this proof and could help present sufferers with some a great deal-essential relief. But further exploration is essential to account for possible confounding aspects that may well have been skipped, this sort of as other environmental variables that may possibly coincide with increased pollen ranges or factors like flower bouquets which could add to flares.

“People may possibly advantage from having antihistamines on times with high pollen levels, or from allergy testing and immunotherapy,” stated Sutcliffe.

This analyze was printed in The Journal of Urology.